2021-4-12 · Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in …
[Morphological characteristics of cell populations in bronchial biopsy from mining-chemical factory workers]. [Article in Russian] Ali-Riza AE(1), Barkhina TG, Samsonova MV, Cherniaev AL. Author information: (1)Research Institute of Human Morphology, 117418, Moscow.
2017-2-16 · The pathology and current concepts of classification of testicular germ cell tumors are reviewed. Michael Mahany.Black Bear at Wibel Mining Camp.Photograph. Anchorage,Alaska. From the Department of Genitourinary Pathology at the Armed Forces Institute of Pathology,Washington, DC. Submitted May 26, 2004; accepted August 16, 2004.
2019-10-24 · Nonneoplastic vocal fold lesions are common that can cause hoarseness and voice change. Reactive lesions of Reinke''s space can be observed in all ages and genders and comprise the majority of the benign nonneoplastic vocal fold lesions. …
2006-11-30 · Rhodes, D.R. et al., 2004, Oncomine: A microarray database and data-mining platform Independent confirmation on transcript levels: What could be the function of these tenascins in the tumor stroma? Tenascin-C Blocks Cell Spreading on Fibronectin and stimulates cell proliferation of cancer cells FN FN/TN T98G phalloidin vinculin
2019-11-19 · Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies. Recent studies reveal that tumor microenvironment (TME) components significantly affect HCC growth and progression, particularly the infiltrating stromal and immune cells. Thus, mining of TME-related biomarkers is crucial to improve the survival of patients with HCC. Public access of The Cancer …
Figure 1. Genes and gene sets induced in the tumor stroma. (a) Hierarchical cluster analysis of tumor cell, tumor stroma and normal stroma samples. A total of 1299 genes was differentially expressed between the tumor stroma and the normal stroma. Heat-map colors represent mean-centered fold change expression in log-space. (b) Well-characterized tumor stroma markers, such as FAPα, Biglycan or ...
The morphometric estimation of parenchyma and stroma condition included the determination of 25 parameters in a prostate gland at 27 persons. The mathematical model of morphogenesis of prostate gland was created by Bayes'' method.
AI in the hands of pathologists enables more reliable results. AI-enabled image analysis with Visiopharm software uses a teach-by-example methodology, which makes finding meaningful differences between biomarkers, cells and tissues straightforward, no matter the tissue type or stain used.
2019-11-26 · Esophageal cancer is the 9th most common cancer, affecting >570.000 people each year worldwide, and the 6th most common cause of cancer related deaths [1]. Currently, the standard treatment for patients with resectable disease is neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Since the addition of nCRT as part of esophageal cancer treatment, survival improved …
2021-10-31 · three markers were quantified by digital pathology both in the tumor and stroma. Then, we developed the immune score based on the density of these three markers and further analyzed its prognostic value. results +The high density of CD3+, CD8 and CD45RO+ T cells both in the tumor and/or stroma were significantly
2012-8-7 · Cell Pathology is a new title re-launched in 2020 in place of Endoplasmic Reticulum Stress in Diseases journal. Cell Pathology is an open-access, peer-reviewed journal that focuses on the abnormal state of cells driven by cell-intrinsic or extrinsic influences that manifest in changes of the morphology, loss of homeostasis, and/or alternations in the genetic profiles of cells. The journal ...
2021-3-9 · Our study provides an objective quantification of the tumour stroma fraction across major types of solid cancer. Findings strongly argue against the commonly promoted view of a general associations between high stroma abundance and poor prognosis. The results also suggest that full exploitation of the prognostic potential of tumour stroma requires analyses that go beyond …
2020-10-21 · In this article of EBioMedicine, Ke Zhao and colleagues [1] show that it is possible to quantify the tumour-stroma percentage by artificial intelligence, using a convolutional neural network on whole-slide images (WSI). Moreover, the prognostic effect of the tumour-stroma ratio (TSR) for overall survival was confirmed, showing the robustness of the TSR method.
· El MF, Braham E, Ayadi A, et al. Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case. Pathology. 2006;38:586–588. 13. Kim NR, Lee JI, Ha SY. Micronodular thymoma with lymphoid stroma in a multilocular thymic cyst: a case study. Korean J Pathol. 2013;47:392 ...
2021-7-9 · 3.3. Tumor/Stroma Expression of UPR-Associated Unfavorable Prognostic Markers in HCC. Metabolic and oncogenic abnormalities in both tumor cells and the surrounding stromal microenvironment are known inducers of ER-stress . HCC is characterized by abundant stroma and develops in a background of sustained inflammation and fibrosis.
2021-10-31 · J. clin. Path. (1958), 11, 19. FOAM CELLS IN THE STROMA OF CARCINOMA OF THE BODY OF THE UTERUS AND UTERINE CERVICAL POLYPI BY HILDA R. HARRIS From the Department of Pathology, the Women''s Hospital, Liverpool (RECEIVED FOR PUBLICATION JANUARY 18, 1957) Dubs (1923) and Nunes (1945) each described a case of adenocarcinoma of the body of …
2013-8-1 · In order to map the extracellular or membrane proteome associated with the vasculature and the stroma in an embryonic organism in vivo, we developed a biotinylation technique for chicken embryo and combined it with mass spectrometry and bioinformatic analysis.We also applied this procedure to implanted tumors growing on the chorioallantoic membrane or after the induction of granulation tissue.
2021-10-3 · Purpose The aim of this study was to explore the effective immune scoring method and mine the novel and potential immune microenvironment-related diagnostic and prognostic markers for cervical squamous cell carcinoma (CSSC). Materials and Methods The Cancer Genome Atlas (TCGA) data was downloaded and multiple data analysis approaches were initially used to search for the immune …
2020-10-28 · 17 the ability to accurately differentiate microglia and macrophage roles in pathology, and identify the consequences of the 18 spatial organization of these cells. 19 Results: Here we characterize the tumor‐stroma border and identify peripheral glioma-associated microglia (PGAM) at 20 the tumor leading edge as a unique subpopulation of GAM.
the combinations of stroma types (stroma variations) are correlated with tumor cell proliferation and expressions of GLUT-1 and MCT-1 by immunohistochemical analysis. *CorrespondenCe to: Taniyama, H., Department of Veterinary Pathology, Rakuno Gakuen University, 582, Bunkyodai-Midori-machi, Ebetsu, Hokkaido 069–8501, Japan.
PDF | We analyze the effect of offline and online triplet mining for colorectal cancer (CRC) histopathology dataset containing 100,000 patches. We... | Find, read and cite all the research you ...
Principle of image annotation, block-based feature extraction and classification. Areas representative of pure tumor epithelium and stroma were identified in the digitized tissue microarray spots ...
Background . Prostate adenocarcinoma (PRAD) is a common malignant tumor in elderly men. Our research uses The Cancer Gene Atlas (TCGA) database to find potential related genes for predicting the prognosis of patients with PRAD. Methods . We downloaded gene expression profiles and clinical sample information from TCGA for 490 patients with PRAD (patient age: 41-78 years).
2010-1-28 · In carcinoma tissues, genetic and metabolic changes not only occur at the tumor cell level, but also in the surrounding stroma. This carcinoma-reactive stromal tissue is heterogeneous and consists e.g. of non-epithelial cells such as fibroblasts or fibrocytes, inflammatory cells and vasculature-related cells, which promote carcinoma growth and progression of carcinomas. Nevertheless, there is ...
2021-3-11 · Using data mining and analyses of samples derived from both murine and human sources we show that PGAM exhibit a pro-inflammatory and chemotactic phenotype that is associated with peripheral monocyte recruitment, and decreased overall survival. PGAM act as a unique subset of GAM at the tumor–stroma interface.
We analyze the effect of offline and online triplet mining for colorectal cancer (CRC) histopathology dataset containing 100,000 patches. We consider the extreme, i.e., farthest and nearest ...
2021-10-26 · Tumor-to-stroma ratio (TSR) is a prognostic factor that expresses the relative amounts of tumor and intratumoral stroma. In this study, its clinical and molecular relevance was evaluated in prostate cancer (PCa). The feasibility of automated quantification was tested in digital scans of tissue microarrays containing 128 primary tumors from 72 PCa patients stained immunohistochemically for ...
2021-7-22 · 4Anatomopathological Diagnosis Center, Pathology Laboratory, João Pessoa, Paraíba, Brazil. ABSTRACT: The tumor stroma plays a relevant role in the initiation and evolution of solid tumors. Tumor-stroma ratio (TSR) is a histological feature that expresses the proportion of the stromal component that surrounds cancer cells.
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